Transgenerational Epigenetics
  • Release Date : 15 August 2019
  • Publisher : Academic Press
  • Categories :
  • Pages : 504 pages
  • ISBN 13 : 0128163631
  • ISBN 10 : 9780128163634
Score: 4
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Synopsis : Transgenerational Epigenetics written by Trygve Tollefsbol, published by Academic Press which was released on 15 August 2019. Download Transgenerational Epigenetics Books now! Available in PDF, EPUB, Mobi Format. Recent research points to the existence of biological phenomena that are controlled not through gene mutations, but rather reversible and heritable epigenetic processes. These processes may have selective or adverse effects on offspring persisting for multiple generations. Transgenerational Epigenetics, Second Edition offers the only up-to-date, comprehensive analysis of the inheritance of epigenetic phenomena between generations with emphasis on human disease relevance, drug discovery, and next steps in clinical translation. Here, international experts discuss mechanisms of epigenetic inheritance, its expression in animal and plant models, and how human ailments, such as metabolic disorders and cardiovascular disease, are influenced by transgenerational epigenetic inheritance. Where evidence is sufficient, epigenetic clinical interventions are proposed that may help prevent disease before the offspring are born, or reduce the severity of disease at the very earliest stages of development in utero. This edition has been thoroughly revised in each disease area, featuring newly researched actors in epigenetic regulation, including long noncoding RNA in addition to histone modifications and DNA methylation. Therapeutic pathways in treating cancer and extending human longevity are also considered, as well as current debates and future directions for research. Fully updated and expanded to address human disease relevance of transgenerational epigenetics, epigenetic mechanisms of gene regulation, and the role of epigenetics in human longevity and cancer Examines the field from "bench-to-bedside," discussing basic science, disease management, current debates, and next steps in epigenetic research and drug discovery Features chapter contributions from international experts