Trace Amines and Neurological Disorders
  • Release Date : 08 August 2016
  • Publisher : Academic Press
  • Categories :
  • Pages : 432 pages
  • ISBN 13 : 0128036036
  • ISBN 10 : 9780128036037
Score: 4
From 245 Ratings

Synopsis : Trace Amines and Neurological Disorders written by Tahira Farooqui, published by Academic Press which was released on 08 August 2016. Download Trace Amines and Neurological Disorders Books now! Available in PDF, EPUB, Mobi Format. "Trace Amines and Neurological Disorders: Potential Mechanisms and Risk Factors" explores trace amines which, under normal conditions, are present in the mammalian brain and peripheral nervous tissues at very low (nanomolar) concentrations. However, in a diverse array of human pathologies ranging from substance abuse, depression, attention deficit hyperactivity disorder, eating disorders, schizophrenia, and other neurological and neuropsychiatric diseases, the levels of trace amines are unusually high with an imbalance in their functions. Furthermore, the rapid turnover of trace amines is evidenced by their dramatic increases following treatment with monoamine oxidase inhibitors (MAOI) or deletion of the MAO genes. This suggests that the concentration of trace amines may be considerably higher at neuronal synapses than predicted by steady-state measures, implicating some pathophysiological role. Therefore, understanding molecular mechanisms and developing selective agonists and antagonists for trace amine-associated receptors (TAARs) has become a good approach for treating these diseases. Although the effects of trace amines at low physiological concentrations in mammalian species have been difficult to demonstrate, they may serve to maintain the neuronal activity of other monoamine neurotransmitters by possessing postsynaptic modulatory effects, particularly dopamine and serotonin, within defined physiological limits. Such an effect of trace amines makes them ideal candidates for the development of novel therapeutics for a wide range of human disorders. This book presents up-to-date, cutting-edge, and comprehensive information on the link between trace amines and neurological disorders. Focuses on recent findings on trace amines, providing insights into the functional significance, molecular mechanisms, and biological relevance of TAARS in neurological disordersEdited work with chapters authored by leaders in the field from around the globe, the broadest, most expert coverage availableProvides cutting-edge research on trace amines-mediated signaling in vertebrate model systems"

Diet and Health

Diet and Health

Author : National Research Council,Division on Earth and Life Studies,Commission on Life Sciences,Committee on Diet and Health
Publisher : National Academies Press
Category : Medical


Author : Jill M. Norvilitis
Publisher : BoD – Books on Demand
Category : Psychology