TDP 43 and Neurodegeneration
  • Release Date : 15 June 2021
  • Publisher : Academic Press
  • Categories : Medical
  • Pages : 300 pages
  • ISBN 13 : 0128200669
  • ISBN 10 : 9780128200667
Score: 4
From 245 Ratings
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Synopsis : TDP 43 and Neurodegeneration written by Vijay Kumar, published by Academic Press which was released on 15 June 2021. Download TDP 43 and Neurodegeneration Books now! Available in PDF, EPUB, Mobi Format. Aggregates of the TAR DNA binding protein 43 (TDP-43), are hallmark features of the neurodegenerative diseases Amyotrophic Lateral Sclerosis (ALS) and frontotemporal dementia (FTD), with overlapping clinical, genetic and pathological features. TDP-43 and Neurodegeneration: From Bench to Bedside summarizes new findings in TDP-43 pathobiology and proteinopathies. The book summarizes TDP-43's structure, function, biology, misfolding, aggregation, pathogenesis and therapeutics. It includes autophagy-mediated therapy, role of stress granule, novel genetic, cell culture based models, systems biology for precision medicine, development of stem cells and mechanism-based therapies that can target ALS and other related neurodegenerative diseases. This book is written for neuroscientists, neurologists, clinicians, advanced graduate students, drug discovery researchers, as well as cellular and molecular biologists involved in ALS, motor neuron disease (MND) and other neurodegenerative disorders. Reviews TDP-43 structure, folding, function, and pathology Identifies TDP-43 role in ALS, FTP, and other neurodegenerative diseases Presents a systems and precision biology perspective of TDP-43 Discusses therapeutics of TDP-43 proteinopathies Translates bench research to application bedside