Molecular Targets in Protein Misfolding and Neurodegenerative Disease
  • Release Date : 07 October 2014
  • Publisher : Academic Press
  • Categories : Science
  • Pages : 314 pages
  • ISBN 13 : 9780128004999
  • ISBN 10 : 0128004991
Score: 4
From 245 Ratings
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Synopsis : Molecular Targets in Protein Misfolding and Neurodegenerative Disease written by Pierfausto Seneci, published by Academic Press which was released on 07 October 2014. Download Molecular Targets in Protein Misfolding and Neurodegenerative Disease Books now! Available in PDF, EPUB, Mobi Format. Aimed at "drug discoverers" – i.e. any scientist who is interested in neurodegenerative diseases in general, and in finding disease-modifying treatments in particular – the first edition of Molecular Targets in Protein Misfolding and Neurodegenerative Disease will contain both a detailed, discipline-specific coverage (paragraphs on medicinal chemistry, on clinical and preclinical characterization of compounds in development, on target identification and validation, on genetic factors influencing a pathology, etc.) and a drug discovery-oriented, overall evaluation of each target (validation, druggability, existing leads, etc.). Together these will satisfy the needs of various audiences, including in vitro biologists, pharmacologists, medicinal chemists, etc. Written to provide a comprehensive coverage of disease-modifying mechanisms and compounds against neurodegenerative diseases Provides a “drug discovery application oriented perspective, evaluating targets and candidates for their overall therapeutic potential Provides discipline-specific chapters (medicinal chemistry, target validation, preclinical and clinical development Provides an overview on a number of molecular mechanisms (e.g. phosphorylation, chaperon refolding, ubiquitination, autophagy, microtubule transportation, protease cleavage, etc.) with relevance for any disease area Contains a more thorough description of the therapeutic relevance of ~10 specific molecular targets

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