Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells
  • Release Date : 29 January 2021
  • Publisher : Academic Press
  • Categories : Science
  • Pages : 200 pages
  • ISBN 13 : 0128206276
  • ISBN 10 : 9780128206270
Score: 4
From 245 Ratings
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Synopsis : Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells written by Sandro Matosevic, published by Academic Press which was released on 29 January 2021. Download Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells Books now! Available in PDF, EPUB, Mobi Format. Breaking Tolerance to Unresponsiveness to Immunotherapy by Natural Killer Cells presents chapters by leaders in translational natural killer cell research and bridges the gap between clinical need and basic science by presenting state-of-the-art knowledge on innate immunity and the challenges associated with translating it to practical adoptive immunotherapies. New approaches, such as the genetic engineering of NK cells and their combination with checkpoint blockade therapies are discussed among other potential interventions to improve natural killer cell functionality against targets. In addition, challenges, such as the difficulty in genetically modifying NK cells or a poor understanding of their effect on checkpoint inhibition are included. The book is a key reference and go-to resource for researchers and clinicians who want to understand the current limitations associated with bringing natural killer cell-based immunotherapies to the clinic. Discusses translational aspects from leaders in the field to facilitate readers' understanding of clinical challenges Addresses important events that occur in patient tumor microenvironments as they pertain to NK cells and how they are, or can be, tackled to overcome immunosuppression of NK cells Focuses on immunometabolism by discussing the metabolic reprogramming that NK cells undergo in solid tumors, including hypoxia, adenosine and other metabolites

Immune Regulation

Immune Regulation

Author : Marc Feldmann,N. A. Mitchison
Publisher : Springer Science & Business Media
Category : Medical
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