Biochemistry of Collagens  Laminins and Elastin
  • Release Date : 29 July 2016
  • Publisher : Academic Press
  • Categories : Science
  • Pages : 272 pages
  • ISBN 13 : 9780128098998
  • ISBN 10 : 0128098996
Score: 5
From 1 Ratings

Synopsis : Biochemistry of Collagens Laminins and Elastin written by Morten Karsdal, published by Academic Press which was released on 29 July 2016. Download Biochemistry of Collagens Laminins and Elastin Books now! Available in PDF, EPUB, Mobi Format. Biochemistry of Collagens, Laminins, and Elastin: Structure, Function, and Biomarkers provides a comprehensive introduction to collagen and structural proteins. Type I collagen is one of the most abundant molecules in the body, playing essential roles in different tissues, particularly bone and skin. A key aspect of type I collagen is its post-translational modifications which are essential for correct synthesis and structural integrity of collagens, for tissue-specific functionality, as well as for application as biomarkers of different pathologies. This volume summarizes current data on key structural proteins (collagens, laminins and elastin), reviews how these molecules affect pathologies, and describes selected modifications of proteins that result in altered signaling properties of the original extracellular matrix component. Further, it discusses the novel concept that an increasing number of components of the ECM harbor cryptic signaling functions that may be viewed as endocrine functions. Additionally, it highlights how this knowledge can be exploited to modulate fibrotic disease. Provides a comprehensive introduction to collagen and structural proteins Provides insight into emerging analytical technologies that can detect biomarkers of extracellular matrix degradation Includes a chapter dedicated to the biomarkers of structural proteins Contains insights into the biochemical interactions and changes to structural composition of proteins in disease states