An Innovative Approach to Understanding and Treating Cancer  Targeting pH
  • Release Date : 16 January 2020
  • Publisher : Academic Press
  • Categories : Science
  • Pages : 574 pages
  • ISBN 13 : 9780128190609
  • ISBN 10 : 0128190604
Score: 4
From 245 Ratings
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Synopsis : An Innovative Approach to Understanding and Treating Cancer Targeting pH written by Tomas Koltai, published by Academic Press which was released on 16 January 2020. Download An Innovative Approach to Understanding and Treating Cancer Targeting pH Books now! Available in PDF, EPUB, Mobi Format. An Innovative Approach to Studying and Treating Cancer: Targeting pH describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognized as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm, mechanisms to decrease extra cellular pH and increase intracellular pH, NHE-1 activity in cancer, carbonic anhydrases, vacuolar ATPase proton pump, and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions, cellular acidification and extracellular alkalinization as a new and integral approach to cancer treatment. Analyzes the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) or with repurposed drugs

Toward Precision Medicine

Toward Precision Medicine

Author : National Research Council,Division on Earth and Life Studies,Board on Life Sciences,Committee on A Framework for Developing a New Taxonomy of Disease
Publisher : National Academies Press
Category : Medical
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