An Innovative Approach to Understanding and Treating Cancer
  • Release Date : 15 February 2020
  • Publisher : Academic Press
  • Categories :
  • Pages : 320 pages
  • ISBN 13 : 0128190590
  • ISBN 10 : 9780128190593
Score: 4
From 245 Ratings
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Synopsis : An Innovative Approach to Understanding and Treating Cancer written by Tomas Koltai, published by Academic Press which was released on 15 February 2020. Download An Innovative Approach to Understanding and Treating Cancer Books now! Available in PDF, EPUB, Mobi Format. The New pH-Centric Paradigm In Cancer Research: From Etiopathogenesis To New Therapeutic Avenues describes one of the few characteristics of cancer that is not shared by normal tissues: the reversal or inversion of the pH gradient, when intracellular pH becomes alkaline and extracellular pH becomes acid. This is now recognised as one of the most selective and differential hallmarks of all cancer cells and tissues, being the opposite of the condition found in normal tissues and a potential target in order to achieve either a stable disease or even regression with no toxicity. The book discusses topics such as lactic acid and its transport system in the pH paradigm; mechanisms to decrease extra cellular pH and increase intracellular pH; NHE-1 activity in cancer; carbonic anhydrases; vacuolar ATPase proton pump; and the sodium-bicarbonate cotransporter system. Additionally, it discusses complementary pharmacological interventions and cellular acidification and extracellular alkalinisation as a new and integral approach to cancer treatment. Analyzes thoroughly the mechanisms that lead to the inversion of pH gradient in cancer tissues Summarizes almost 100 years of research on pH inversion in cancer in one single source, discussing the most relevant and updated researches in the field Proposes new efficient treatments against cancer using pH inversion mechanisms, either with new drugs like proton transport inhibitors and proton pump inhibitors (PTIs and PPIs) as well as with repurposed drugs

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